There are three important aspects to my teaching philosophy –
(a) Ensuring every student is engaged in the classroom activity.
(b) Making students understand the implications of concepts taught in class by connecting them to direct functions in our daily life.
(c) Making science more accessible by furthering the discourse to include seminal research.
I have received my PhD in Medicinal Chemistry from the University of Illinois after which I was a postdoctoral fellow at Stanford University. I have experience teaching advanced biochemistry to undergrads.
Currently, I am working as a scientist in a biotech company.
EDUCATION AND TRAINING
Postdoc Stanford University
Molecular and Cellular Physiology September 2014 – Mar 2020
PhD University of Illinois at Chicago
Medicinal Chemistry August 2010 – August 2014
Dissertation – Intra and Intermolecular Interactions of K-Ras4B
BS University of Pune, India
Pharmaceutical Sciences May 2006 – May 2010
• Introductory through Advanced Biochemistry
• Introductory and Intermediate Chemistry and Biology
TEACHING AND RESEARCH EXPERIENCE
Post-Doctoral Research Scholar, Stanford University Sep 2014 – Mar 2020
• Mentored and trained high school students for their summer projects and graduate students for their rotation projects.
• Worked on multiple collaborations that led to significant publications.
• Designed and executed experiments to study conformational and functional changes in membrane transporters.
• Assisted in writing and editing of research manuscripts.
Teaching Assistant, University of Illinois at Chicago Jan 2011 – May 2011
• Conducted and graded exams and corrected homework for an advanced biochemistry course.
• Conducted discussion sessions for an undergraduate class twice a week for 30+ students.
• Taught as an occasional substitute teacher for the course.
Graduate Researcher, University of Illinois at Chicago Aug 2010 – Aug 2014
• Mentored undergraduate students in the lab who then presented their work at research forums.
• Designed, led and implemented multi-disciplinary research projects that resulted in several impactful publications.
• Assisted in writing and editing of research proposals and papers.
• Expressed and purified several kinds of proteins and developed assays to characterize structural and functional changes in oncogenic Ras proteins.
HONORS AND AWARDS
• Received the WE van Doren Scholar Award from the Department of Medicinal Chemistry, University of Illinois at Chicago in March 2014.
• Received the Charles Bell Award from the Department of Medicinal Chemistry, University of Illinois at Chicago in Feb 2013.
• Third rank in Poster Presentation organized by the Indian Pharmaceutical Association at a national level in Nov 2006.
• Second Prize in National-level Inter-collegiate Competition on the topic “Invention Project of Young Pharmaceutical Scientists” in Jan 2007.
SELECTED PUBLICATIONS (Out of 14)
1. Chavan TS, Cheng RC, Jiang T, Mathews II, Stein RA, Koehl A, Mchaourab HS, Tajkhorshid E, Maduke M; A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl-/H+ transport cycle; eLife manuscript under review.
2. Chavan TS, Jang H, Khavrutskii L, Abraham SJ, Freed BC, Tarasov SG, Gaponenko V, Nussinov R, Tarasova NI; High affinity interaction of K-Ras4B hypervariable region with Ras active site, Biophysical Journal 109(12), 2015, 2602-13.
3. Chavan TS, Meyer J, Dobosz M, Chisholm L, Gaponenko V; A Novel Method for the Production of Fully modified K-Ras 4B, Methods in Molecular Biology 1120,2014,19-34.
4. Chavan TS, Abraham S, Gaponenko V; Application of reductive 13C-methylation of lysines to enhance the sensitivity of conventional NMR methods, Molecules 18(6) 2013, 7103-19.
SELECTED CONFERENCE PRESENTATIONS
• Talk on Characterizing conformational changes in CLC Cl-/H+ antiporters at the Advanced Light Source User’s Meeting in October 2017 at the Lawrence Berkeley National Laboratory.
• Poster presentation on Elucidating Mechanisms of CXCR4 Inhibitors using Reductive Methylation at the 14th Annual GPCR Retreat 2013 at Cleveland, Ohio and at the Chicago Biomedical Consortium 2013 at University of Chicago.
• Talk and poster presentation on Modes of binding between the fully post-translationally modified hypervariable region of K-Ras and Calmodulin at the Keystone Symposia in Molecular and Cellular Biology (Frontiers of NMR in Biology) 2013 at Snowbird, UT and at the 7th Midwest Conference on Protein Folding in April 2012 at the University of Notre Dame, South Bend, IN.
• Poster presentation on Investigating conformational changes to understand the transport mechanism of CLC antiporters at the 64th Annual Biophysical Society Meeting in February 2020 at San Diego, CA.
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